“Oncoslice”; Microfluidic Drug Delivery for Pre-Clinical Screening of Patient Derived Tumor Cultures
The in silico predictions provided by genomic analyses do not always reliably predict actual patient treatment responses. In collaboration with the Folch lab and Ray Monnat at the University of Washington, Departments of Bioengineering and Genome Sciences we developed and tested a novel pre-clinical screening platform to bridge this gap. Using a microfluidic platform, multiple drugs are delivered to tumor derived slice cultures. Current research is focused on validation of predictive power in animal models, testing of immunotherapies and alternative tissue formats (3D bioprinting and tumor spheroids).
PMIDs: 32435696, 32270149