Selected Basic and Translational Research Publications

Brachi G, Ruiz-Ramírez J, Dogra P, Wang Z, Cristini V, Ciardelli G, Rostomily RC, Ferrari M, Mikheev AM, Blanco E, Mattu C. Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma. Nanoscale. 2020 Nov 25. doi: 10.1039/d0nr05053a. Epub ahead of print. PMID: 33237080.

Rodriguez, A. D., L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, and A. Folch. “A Microfluidic Platform for Functional Testing of Cancer Drugs on Intact Tumor Slices.” Lab Chip 20, no. 9 (May 7 2020): 1658-75. https://dx.doi.org/10.1039/c9lc00811j.

Parada, C. A., J. W. Osbun, T. Busald, Y. Karasozen, S. Kaur, M. Shi, J. Barber, W. Adidharma, P. J. Cimino, C. Pan, L. F. Gonzalez-Cuyar, R. Rostomily, D. E. Born, J. Zhang, and M. Ferreira, Jr. “Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals Rb1 Signaling as a Novel Mediator and Biomarker.” Clin Cancer Res 26, no. 1 (Jan 1 2020): 193-205. https://dx.doi.org/10.1158/1078-0432.Ccr-18-0641.

Horowitz, L. F., A. D. Rodriguez, Z. Dereli-Korkut, R. Lin, K. Castro, A. M. Mikheev, R. J. Monnat, Jr., A. Folch, and R. C. Rostomily. “Multiplexed Drug Testing of Tumor Slices Using a Microfluidic Platform.” NPJ Precis Oncol 4 (2020): 12. https://dx.doi.org/10.1038/s41698-020-0117-y.

Wong, K. K., R. Rostomily, and S. T. C. Wong. “Prognostic Gene Discovery in Glioblastoma Patients Using Deep Learning.” Cancers (Basel) 11, no. 1 (Jan 8 2019). https://dx.doi.org/10.3390/cancers11010053.

Mikheeva, S. A., N. D. Camp, L. Huang, A. Jain, S. Y. Jung, N. G. Avci, M. Tokita, A. Wolf-Yadlin, J. Zhang, S. J. Tapscott, R. C. Rostomily, and A. M. Mikheev. “Twist1 Heterodimerization with E12 Requires Coordinated Protein Phosphorylation to Regulate Periostin Expression.” Cancers (Basel) 11, no. 9 (Sep 18 2019). https://dx.doi.org/10.3390/cancers11091392.

Puchalski, R. B., N. Shah, J. Miller, R. Dalley, S. R. Nomura, J. G. Yoon, K. A. Smith, M. Lankerovich, D. Bertagnolli, K. Bickley, A. F. Boe, K. Brouner, S. Butler, S. Caldejon, M. Chapin, S. Datta, N. Dee, T. Desta, T. Dolbeare, N. Dotson, A. Ebbert, D. Feng, X. Feng, M. Fisher, G. Gee, J. Goldy, L. Gourley, B. W. Gregor, G. Gu, N. Hejazinia, J. Hohmann, P. Hothi, R. Howard, K. Joines, A. Kriedberg, L. Kuan, C. Lau, F. Lee, H. Lee, T. Lemon, F. Long, N. Mastan, E. Mott, C. Murthy, K. Ngo, E. Olson, M. Reding, Z. Riley, D. Rosen, D. Sandman, N. Shapovalova, C. R. Slaughterbeck, A. Sodt, G. Stockdale, A. Szafer, W. Wakeman, P. E. Wohnoutka, S. J. White, D. Marsh, R. C. Rostomily, L. Ng, C. Dang, A. Jones, B. Keogh, H. R. Gittleman, J. S. Barnholtz-Sloan, P. J. Cimino, M. S. Uppin, C. D. Keene, F. R. Farrokhi, J. D. Lathia, M. E. Berens, A. Iavarone, A. Bernard, E. Lein, J. W. Phillips, S. W. Rostad, C. Cobbs, M. J. Hawrylycz, and G. D. Foltz. “An Anatomic Transcriptional Atlas of Human Glioblastoma.” Science 360, no. 6389 (May 11 2018): 660-63. https://dx.doi.org/10.1126/science.aaf2666.

Parada, C. A., J. Osbun, S. Kaur, Y. Yakkioui, M. Shi, C. Pan, T. Busald, Y. Karasozen, L. F. Gonzalez-Cuyar, R. Rostomily, J. Zhang, and M. Ferreira, Jr. “Kinome and Phosphoproteome of High-Grade Meningiomas Reveal Akap12 as a Central Regulator of Aggressiveness and Its Possible Role in Progression.” Sci Rep 8, no. 1 (Feb 1 2018): 2098. https://dx.doi.org/10.1038/s41598-018-19308-y.

Mikheev, A. M., S. A. Mikheeva, L. J. Severs, C. C. Funk, L. Huang, J. L. McFaline-Figueroa, J. Schwensen, C. Trapnell, N. D. Price, S. Wong, and R. C. Rostomily. “Targeting Twist1 through Loss of Function Inhibits Tumorigenicity of Human Glioblastoma.” Mol Oncol 12, no. 7 (Jun 2018): 1188-202. https://dx.doi.org/10.1002/1878-0261.12320.

Pollak, J., K. G. Rai, C. C. Funk, S. Arora, E. Lee, J. Zhu, N. D. Price, P. J. Paddison, J. M. Ramirez, and R. C. Rostomily. “Ion Channel Expression Patterns in Glioblastoma Stem Cells with Functional and Therapeutic Implications for Malignancy.” PLoS One 12, no. 3 (2017): e0172884. https://dx.doi.org/10.1371/journal.pone.0172884.

Mikheev, A. M., S. A. Mikheeva, M. Tokita, L. J. Severs, and R. C. Rostomily. “Twist1 Mediated Regulation of Glioma Tumorigenicity Is Dependent on Mode of Mouse Neural Progenitor Transformation.” Oncotarget 8, no. 64 (Dec 8 2017): 107716-29. https://dx.doi.org/10.18632/oncotarget.22593.

Underhill, H. R., J. O. Kitzman, S. Hellwig, N. C. Welker, R. Daza, D. N. Baker, K. M. Gligorich, R. C. Rostomily, M. P. Bronner, and J. Shendure. “Fragment Length of Circulating Tumor DNA.” PLoS Genet 12, no. 7 (Jul 2016): e1006162. https://dx.doi.org/10.1371/journal.pgen.1006162.

Mikheev, A. M., S. A. Mikheeva, A. D. Trister, M. J. Tokita, S. N. Emerson, C. A. Parada, D. E. Born, B. Carnemolla, S. Frankel, D. H. Kim, R. G. Oxford, Y. Kosai, K. R. Tozer-Fink, T. C. Manning, J. R. Silber, and R. C. Rostomily. “Periostin Is a Novel Therapeutic Target That Predicts and Regulates Glioma Malignancy.” Neuro Oncol 17, no. 3 (Mar 2015): 372-82. https://dx.doi.org/10.1093/neuonc/nou161.

Chu, D. S., M. J. Bocek, J. Shi, A. Ta, C. Ngambenjawong, R. C. Rostomily, and S. H. Pun. “Multivalent Display of Pendant Pro-Apoptotic Peptides Increases Cytotoxic Activity.” J Control Release 205 (May 10 2015): 155-61. https://dx.doi.org/10.1016/j.jconrel.2015.01.013.

Kumar, A., E. A. Boyle, M. Tokita, A. M. Mikheev, M. C. Sanger, E. Girard, J. R. Silber, L. F. Gonzalez-Cuyar, J. B. Hiatt, A. Adey, C. Lee, J. O. Kitzman, D. E. Born, D. L. Silbergeld, J. M. Olson, R. C. Rostomily, and J. Shendure. “Deep Sequencing of Multiple Regions of Glial Tumors Reveals Spatial Heterogeneity for Mutations in Clinically Relevant Genes.” Genome Biol 15, no. 12 (Dec 3 2014): 530. https://dx.doi.org/10.1186/s13059-014-0530-z.

Chang, T. C., A. M. Mikheev, W. Huynh, R. J. Monnat, R. C. Rostomily, and A. Folch. “Parallel Microfluidic Chemosensitivity Testing on Individual Slice Cultures.” Lab Chip 14, no. 23 (Dec 7 2014): 4540-51. https://dx.doi.org/10.1039/c4lc00642a.

Stoll, E. A., P. J. Horner, and R. C. Rostomily. “The Impact of Age on Oncogenic Potential: Tumor-Initiating Cells and the Brain Microenvironment.” Aging Cell 12, no. 5 (Oct 2013): 733-41. https://dx.doi.org/10.1111/acel.12104.

Mikheev, A. M., E. A. Stoll, R. Ramakrishna, S. A. Mikheeva, P. J. Horner, and R. C. Rostomily. “Geropotency: Increased Malignant Potential of Aging Neural Progenitors.” Aging (Albany NY) 4, no. 12 (Dec 2012): 854-5. https://dx.doi.org/10.18632/aging.100514.

Mikheev, A. M., R. Ramakrishna, E. A. Stoll, S. A. Mikheeva, R. P. Beyer, D. A. Plotnik, J. L. Schwartz, J. K. Rockhill, J. R. Silber, D. E. Born, Y. Kosai, P. J. Horner, and R. C. Rostomily. “Increased Age of Transformed Mouse Neural Progenitor/Stem Cells Recapitulates Age-Dependent Clinical Features of Human Glioma Malignancy.” Aging Cell 11, no. 6 (Dec 2012): 1027-35. https://dx.doi.org/10.1111/acel.12004.

Underhill, H. R., R. C. Rostomily, A. M. Mikheev, C. Yuan, and V. L. Yarnykh. “Fast Bound Pool Fraction Imaging of the in Vivo Rat Brain: Association with Myelin Content and Validation in the C6 Glioma Model.” Neuroimage 54, no. 3 (Feb 1 2011): 2052-65. https://dx.doi.org/10.1016/j.neuroimage.2010.10.065.

Stoll, E. A., B. A. Habibi, A. M. Mikheev, J. Lasiene, S. C. Massey, K. R. Swanson, R. C. Rostomily, and P. J. Horner. “Increased Re-Entry into Cell Cycle Mitigates Age-Related Neurogenic Decline in the Murine Subventricular Zone.” Stem Cells 29, no. 12 (Dec 2011): 2005-17. https://dx.doi.org/10.1002/stem.747.

Stoll, E. A., W. Cheung, A. M. Mikheev, I. R. Sweet, J. H. Bielas, J. Zhang, R. C. Rostomily, and P. J. Horner. “Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism.” J Biol Chem 286, no. 44 (Nov 4 2011): 38592-601. https://dx.doi.org/10.1074/jbc.M111.252171.

Mathieu, J., Z. Zhang, W. Zhou, A. J. Wang, J. M. Heddleston, C. M. Pinna, A. Hubaud, B. Stadler, M. Choi, M. Bar, M. Tewari, A. Liu, R. Vessella, R. Rostomily, D. Born, M. Horwitz, C. Ware, C. A. Blau, M. A. Cleary, J. N. Rich, and H. Ruohola-Baker. “Hif Induces Human Embryonic Stem Cell Markers in Cancer Cells.” Cancer Res 71, no. 13 (Jul 1 2011): 4640-52. https://dx.doi.org/10.1158/0008-5472.Can-10-3320.

Rostomily, R. C., D. E. Born, R. P. Beyer, J. Jin, E. C. Alvord, Jr., A. M. Mikheev, R. T. Matthews, C. Pan, L. Khorasani, J. A. Sonnen, T. J. Montine, M. Shi, and J. Zhang. “Quantitative Proteomic Analysis of Oligodendrogliomas with and without 1p/19q Deletion.” J Proteome Res 9, no. 5 (May 7 2010): 2610-8. https://dx.doi.org/10.1021/pr100054v.

Mikheeva, S. A., A. M. Mikheev, A. Petit, R. Beyer, R. G. Oxford, L. Khorasani, J. P. Maxwell, C. A. Glackin, H. Wakimoto, I. González-Herrero, I. Sánchez-García, J. R. Silber, P. J. Horner, and R. C. Rostomily. “Twist1 Promotes Invasion through Mesenchymal Change in Human Glioblastoma.” Mol Cancer 9 (Jul 20 2010): 194. https://dx.doi.org/10.1186/1476-4598-9-194.

Rhee, W., S. Ray, H. Yokoo, M. E. Hoane, C. C. Lee, A. M. Mikheev, P. J. Horner, and R. C. Rostomily. “Quantitative Analysis of Mitotic Olig2 Cells in Adult Human Brain and Gliomas: Implications for Glioma Histogenesis and Biology.” Glia 57, no. 5 (Apr 1 2009): 510-23. https://dx.doi.org/10.1002/glia.20780.

Mikheev, A. M., E. A. Stoll, S. A. Mikheeva, J. P. Maxwell, P. P. Jankowski, S. Ray, T. Uo, R. S. Morrison, P. J. Horner, and R. C. Rostomily. “A Syngeneic Glioma Model to Assess the Impact of Neural Progenitor Target Cell Age on Tumor Malignancy.” Aging Cell 8, no. 4 (Aug 2009): 499-501. https://dx.doi.org/10.1111/j.1474-9726.2009.00494.x.

Elias, M. C., K. R. Tozer, J. R. Silber, S. Mikheeva, M. Deng, R. S. Morrison, T. C. Manning, D. L. Silbergeld, C. A. Glackin, T. A. Reh, and R. C. Rostomily. “Twist Is Expressed in Human Gliomas and Promotes Invasion.” Neoplasia 7, no. 9 (Sep 2005): 824-37. https://dx.doi.org/10.1593/neo.04352.

Rostomily, R. C., O. Bermingham-McDonogh, M. S. Berger, S. J. Tapscott, T. A. Reh, and J. M. Olson. “Expression of Neurogenic Basic Helix-Loop-Helix Genes in Primitive Neuroectodermal Tumors.” Cancer Res 57, no. 16 (Aug 15 1997): 3526-31.

Selected Clinical Publications

Ren, D., H. Cheng, X. Wang, M. Vishnoi, B. S. Teh, R. Rostomily, J. Chang, S. T. Wong, and H. Zhao. “Emerging Treatment Strategies for Breast Cancer Brain Metastasis: From Translational Therapeutics to Real-World Experience.” Ther Adv Med Oncol 12 (2020): 1758835920936151. https://dx.doi.org/10.1177/1758835920936151.

Haque, W., Y. Thong, V. Verma, R. Rostomily, E. Brian Butler, and B. S. Teh. “Patterns of Management and Outcomes of Unifocal Versus Multifocal Glioblastoma.” J Clin Neurosci 74 (Apr 2020): 155-59. https://dx.doi.org/10.1016/j.jocn.2020.01.086.

Ramakrishna, R., A. Hebb, J. Barber, R. Rostomily, and D. Silbergeld. “Outcomes in Reoperated Low-Grade Gliomas.” Neurosurgery 77, no. 2 (Aug 2015): 175-84; discussion 84. https://dx.doi.org/10.1227/neu.0000000000000753.

Bobola, M. S., M. Alnoor, J. Y. Chen, D. D. Kolstoe, D. L. Silbergeld, R. C. Rostomily, A. Blank, M. C. Chamberlain, and J. R. Silber. “O(6)-Methylguanine-DNA Methyltransferase Activity Is Associated with Response to Alkylating Agent Therapy and with Mgmt Promoter Methylation in Glioblastoma and Anaplastic Glioma.” BBA Clin 3 (Jun 1 2015): 1-10. https://dx.doi.org/10.1016/j.bbacli.2014.11.003.

Baldock, A. L., S. Ahn, R. Rockne, S. Johnston, M. Neal, D. Corwin, K. Clark-Swanson, G. Sterin, A. D. Trister, H. Malone, V. Ebiana, A. M. Sonabend, M. Mrugala, J. K. Rockhill, D. L. Silbergeld, A. Lai, T. Cloughesy, G. M. McKhann, 2nd, J. N. Bruce, R. C. Rostomily, P. Canoll, and K. R. Swanson. “Patient-Specific Metrics of Invasiveness Reveal Significant Prognostic Benefit of Resection in a Predictable Subset of Gliomas.” PLoS One 9, no. 10 (2014): e99057. https://dx.doi.org/10.1371/journal.pone.0099057.

Ramakrishna, R., and R. Rostomily. “Seed, Soil, and Beyond: The Basic Biology of Brain Metastasis.” Surg Neurol Int 4, no. Suppl 4 (2013): S256-64. https://dx.doi.org/10.4103/2152-7806.111303.

Ramakrishna, R., J. Barber, G. Kennedy, A. Rizvi, R. Goodkin, R. H. Winn, G. A. Ojemann, M. S. Berger, A. M. Spence, and R. C. Rostomily. “Imaging Features of Invasion and Preoperative and Postoperative Tumor Burden in Previously Untreated Glioblastoma: Correlation with Survival.” Surg Neurol Int 1 (Aug 10 2010). https://dx.doi.org/10.4103/2152-7806.68337.

Swanson, K. R., R. C. Rostomily, and E. C. Alvord, Jr. “A Mathematical Modelling Tool for Predicting Survival of Individual Patients Following Resection of Glioblastoma: A Proof of Principle.” Br J Cancer 98, no. 1 (Jan 15 2008): 113-9. https://dx.doi.org/10.1038/sj.bjc.6604125.

Spence, A. M., M. Muzi, K. R. Swanson, F. O’Sullivan, J. K. Rockhill, J. G. Rajendran, T. C. Adamsen, J. M. Link, P. E. Swanson, K. J. Yagle, R. C. Rostomily, D. L. Silbergeld, and K. A. Krohn. “Regional Hypoxia in Glioblastoma Multiforme Quantified with [18f]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival.” Clin Cancer Res 14, no. 9 (May 1 2008): 2623-30. https://dx.doi.org/10.1158/1078-0432.Ccr-07-4995.

Douglas, J. G., K. J. Stelzer, D. A. Mankoff, K. S. Tralins, K. A. Krohn, M. Muzi, D. L. Silbergeld, R. C. Rostomily, J. Scharnhorst, and A. M. Spence. “[F-18]-Fluorodeoxyglucose Positron Emission Tomography for Targeting Radiation Dose Escalation for Patients with Glioblastoma Multiforme: Clinical Outcomes and Patterns of Failure.” Int J Radiat Oncol Biol Phys 64, no. 3 (Mar 1 2006): 886-91. https://dx.doi.org/10.1016/j.ijrobp.2005.08.013.

Bobola, M. S., M. J. Emond, A. Blank, E. H. Meade, D. D. Kolstoe, M. S. Berger, R. C. Rostomily, D. L. Silbergeld, A. M. Spence, and J. R. Silber. “Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and after Radiotherapy.” Clin Cancer Res 10, no. 23 (Dec 1 2004): 7875-83. https://dx.doi.org/10.1158/1078-0432.Ccr-04-1161.

Silbergeld, D. L., R. C. Rostomily, and E. C. Alvord, Jr. “The Cause of Death in Patients with Glioblastoma Is Multifactorial: Clinical Factors and Autopsy Findings in 117 Cases of Supratentorial Glioblastoma in Adults.” J Neurooncol 10, no. 2 (Apr 1991): 179-85. https://dx.doi.org/10.1007/bf00146880.

Rostomily, R. C., M. S. Berger, G. A. Ojemann, and E. Lettich. “Postoperative Deficits and Functional Recovery Following Removal of Tumors Involving the Dominant Hemisphere Supplementary Motor Area.” J Neurosurg 75, no. 1 (Jul 1991): 62-8. https://dx.doi.org/10.3171/jns.1991.75.1.0062

Book Chapters

Vishnoi M, Scranton RA, Asante SK, Rostomily RC. (2020) Basic Biology of Brain Metastasis. In: Ramakrishna R., Magge R., Baaj A., Knisely J. (eds) Central Nervous System Metastases. Springer, Cham.
“https://link.springer.com/chapter/10.1007/978-3-030-42958-4_2”>https://link.springer.com/chapter/10.1007/978-3-030-42958-4_2

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