Funding

Active:

NIH/NCI U01; Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay; (Robert Rostomily Co-PI, Karol Bomsztyk UW Co-PI).
NIH/NCI R01; Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors; (Stephen Wong PI; Robert Rostomily Co-Investigator).
CPRIT-Cancer Prevention and Research Initiative of Texas; Leveraging Glioma Stem Cell Electrophysiology for Therapy; (Robert Rostomily PI, Francois St. Pierre and Ben Arenkiel BCM, Co-Investigators).
Golfers Against Cancer; Repurposing of DYRK1A inhibitors for GBM treatment; (Andrei Mikheev and Robert Rostomily, Co-PIs).
CPRIT-Cancer Prevention and Research Initiative of Texas; A Novel Organoid Platform to Modulate Human Neural Networks Integrated with Glioblastoma Stem Cells (Robert Krencik PI, Rostomily Co-Investigator).
Houston Methodist Foundation; TSPO PET imaging of brain metastases; (Rostomily PI).

Recently Completed:

Neuro SPARK; Neuro-restoration of treatment induced myelin injury in a preclinical glioma model (Rostomily and Horner Co-PIs).
CPRIT-Cancer Prevention and Research Initiative of Texas; Development of a mini-pig glioma model and validation of human clinical relevance (Rostomily and Horner co-PIs).
NIH/NINDS R01; Therapeutically Relevant Targets of TWIST1 Dimers in Glioma; (Robert Rostomily PI).

Papers

Selected Basic and Translational Research:
Pandey A, Tripathi SC, Mai J, Hanash SM, Shen H, Mitra S, Rostomily RC. “Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma.” Cancers (Basel). 2021 Oct 12;13(20):5114. doi: 10.3390/cancers13205114.PMID: 34680264

Brachi G , Ruiz-Ramírez J , Dogra P , Wang Z , Cristini V , Ciardelli G , Rostomily RC , Ferrari M , Mikheev AM , Blanco E , Mattu C. “Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma.” Nanoscale. 2020 Dec 8;12(46):23838-23850. doi: 10.1039/d0nr05053a.PMID: 33237080

Selected Clinical Publications:
Chevli N, Wang HC, Dubey P, Haque W, Farach AM, Pino R, Rostomily RC, Butler EB, Teh BS. “Staged Stereotactic Radiosurgery Decreases Symptomatic Radionecrosis in Large Brain Metastasis.” Anticancer Res. 2021 Mar;41(3):1445-1449. doi: 10.21873/anticanres.14902.PMID: 33788736

Zanotti-Fregonara P, Pascual B, Rostomily RC, Rizzo G, Veronese M, Masdeu JC, Turkheimer F. “Anatomy of 18F-GE180, a failed radioligand for the TSPO protein.” Eur J Nucl Med Mol Imaging. 2020 Sep;47(10):2233-2236. doi: 10.1007/s00259-020-04732-y. Epub 2020 Feb 22.PMID: 32088848.

Scranton RA, Hsiao KY, Sadrameli SS, Wang HC, Thong Y, Garcia Luzardo P, Fung SH, Pino R, Farach AM, Butler EB, Teh B, Rostomily RC. “Combinatorial Anatomic and Functional Neural Tract Mapping for Stereotactic Radiosurgery Planning.” Cureus. 2019 Nov 14;11(11):e6161. doi: 10.7759/cureus.6161.PMID: 31890369

Scranton RA, Sadrameli S, Butler EB, Farach A, Wang HC, Teh BS, Tremont-Lukats IW, Fung SH, Zanotti-Fregonara P, Rostomily RC. “Coregistration of Magnetic Resonance and [18F] Fludeoxyglucose-Positron Emission Tomography Imaging for Stereotactic Radiation Therapy Planning: Case Report in a Previously Irradiated Brain Metastasis With Recurrent Tumor and Radiation Necrosis.” Pract Radiat Oncol. 2020 Mar-Apr;10(2):133-137. doi: 10.1016/j.prro.2019.11.008. Epub 2019 Nov 29.PMID: 31790826

Special Issue– Cancers (ISSN 2072-6694, IF 6.16) “Systems Biology and Intra-Tumoral Heterogeneity” For this Special Issue, co-editors Drs Rostomily and Wong, are soliciting manuscripts focused on theoretical or translational Systems Biology approaches that provide insight into the clinical implications and complexities of intra-tumoral heterogeneity.

Submission deadline:  31 January 2021
Website: https://www.mdpi.com/journal/cancers/special_issues/LPA
Contacts:  rrostomily@houstonmethodist.org or STWong@houstonmethodist.org.

Two new “Oncoslice” publications. In collaboration with the Folch lab at the UW we recently published on the technical development and translational application of the microfluidic drug delivery device using xenograft and patient derived cancer slice cultures.

“A Microfluidic Platform for Functional Testing of Cancer Drugs on Intact Tumor Slices.” Lab Chip 20, no. 9 (May 7 2020): 1658-75. https://dx.doi.org/10.1039/c9lc00811j.

“Multiplexed Drug Testing of Tumor Slices Using a Microfluidic Platform.” NPJ Precis Oncol 4 (2020): 12. https://dx.doi.org/10.1038/s41698-020-0117-y.
See the story behind the paper here: https://cancercommunity.nature.com/posts/a-marriage-of-tumor-slices-and-microfluidics?badge_id=620-npj-precision-oncol

Congrats to Svetlana and Andrei (et al).  Their work outlining the novel role of TWIST1 phosphorylation and dimer motifs in regulating Periostin expression and invasion in GBM cells was published in Cancers.”Twist1 Heterodimerization with E12 Requires Coordinated Protein Phosphorylation to Regulate Periostin Expression.” Cancers (Basel) 11, no. 9 (Sep 18 2019). https://dx.doi.org/10.3390/cancers11091392.

Novel biomarker for aggressive meningiomas.  Our collaborator Carolina Parada from the Ferriera lab at the UW just published in Clinical Cancer Research.  “Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals Rb1 Signaling as a Novel Mediator and Biomarker.” Clin Cancer Res 26, no. 1 (Jan 1 2020): 193-205. https://dx.doi.org/10.1158/1078-0432.Ccr-18-0641.

Book chapter: Congrats to Monika Vishnoi et al for their comprehensive treatise on the basic biology of brain metastasis and for lab alumnus, Rohan Ramakrishna, on editing this authoritative book.
Vishnoi M, Scranton RA, Asante SK, Rostomily RC. (2020) Basic Biology of Brain Metastasis. In: Ramakrishna R., Magge R., Baaj A., Knisely J. (eds) Central Nervous System Metastases. Springer, Cham.
https://link.springer.com/chapter/10.1007/978-3-030-42958-4_2

Presentations

Congrats to Monika Vishnoi, PhD whose abstract “Matrisome Signatures in GBM Heterogeneity” was selected for presentation as a Short Talk at the Keystone Symposia on Proteomics in Cell Biology and Disease, September 21, 2020.

Moving On

Zeynep Dereli-Korkut is moving on from her post-doc to accept a position as a research scientist at MD Anderson.  Best of luck Zeynep and look forward to continued collaborations.

Pooja Gandhi has moved to MD Anderson, where she has taken a position as Institute Research Scientist in TRACTION.  Best of luck Pooja!